Pre-cancer of Vagina (VAIN)
If you have history of the following risk factors then talk to our Consultants:
Concurrent or prior cervical intraepithelial neoplasia CIN
Or vulvar intraepithelial neoplasia VIN (both present in more than three-quarters of patients)
HPV infection
Or sexually transmitted diseases
Smoking, immunosuppression
History of radiation therapy or DES exposure
VAIN has 10–42% overall recurrence rate
2–12% rate of development of invasive squamous carcinoma
Age range:
16 years – 84 years (mean 35–55 years)
Symptoms:
Commonly asymptomatic
Detection typically following Pap smear
Rarely, vaginal bleeding or discharge
However it can be benign condition like:
Nonspecific squamous hyperplasia
Immature squamous metaplasia
Reactive inflammatory atypia
Atrophy
Micro papillomatosis